Immunogenicity of a lambda phage-based anti-cancer vaccine targeting HAAH
نویسندگان
چکیده
منابع مشابه
Immunogenicity of a lambda phage-based anti-cancer vaccine targeting HAAH
We have designed, developed and produced a lambdaphage based anti-cancer vaccine (nano-particle) targeting human aspartyl (asparaginyl) b-hydroxylase (HAAH). This follows accumulated evidence that HAAH meets requirements of a good target for anti-cancer immunotherapy. The protein is over-expressed on the surface of cancer cells and plays a central role in cancer etiology that effects cancer cel...
متن کاملInhibition of tumor growth in vivo by a nanoparticle-based therapeutic cancer vaccine targeting HAAH
We have designed, developed and produced a lambdaphage based therapeutic anti-cancer vaccine (nanoparticle) targeting human aspartyl (asparaginyl) b-hydroxylase (HAAH). This protein is over-expressed on the surface of cancer cells and plays a central role in cancer etiology that affects cancer cell growth, motility and invasiveness. To overcome the self-antigen tolerance of the molecule, we hav...
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Background We are evaluating the immunogenicity and efficacy of a nanoparticle vaccine (NPV) targeting the tumor marker human aspartyl (asparaginyl) b-hydroxylase (HAAH). HAAH is an embryonic protein that is over-expressed on the surface of cancer cells, is demonstrated to be responsible for cell proliferation, motility and invasiveness, processes which can be inhibited by anti-HAAH antibodies ...
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Background We are evaluating the immunogenicity and efficacy of a nanoparticle vaccine (NPV) targeting the tumor marker human aspartyl (asparaginyl) b-hydroxylase (HAAH). HAAH is an embryonic protein that is over-expressed on the surface of cancer cells, is demonstrated to be responsible for cell proliferation, motility and invasiveness, processes which can be inhibited by anti-HAAH antibodies ...
متن کاملLambda phage-based vaccine induces antitumor immunity in hepatocellular carcinoma
BACKGROUND AND AIMS Hepatocellular carcinoma (HCC) is a difficult to treat tumor with a poor prognosis. Aspartate β-hydroxylase (ASPH) is a highly conserved enzyme overexpressed on the cell surface of both murine and human HCC cells. METHODS We evaluated therapeutic effects of nanoparticle lambda (λ) phage vaccine constructs against ASPH expressing murine liver tumors. Mice were immunized bef...
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ژورنال
عنوان ژورنال: Journal for ImmunoTherapy of Cancer
سال: 2013
ISSN: 2051-1426
DOI: 10.1186/2051-1426-1-s1-p210